POLYAMINE OXIDASE ACTIVITY IN HUMAN PREGNANCY SERUM
- 1 November 1979
- journal article
- Published by Wiley in BJOG: An International Journal of Obstetrics and Gynaecology
- Vol. 86 (11), 878-881
- https://doi.org/10.1111/j.1471-0528.1979.tb10715.x
Abstract
The existence of a spermine oxidizing enzyme was established in human pregnancy serum by a radiochemical method, and a cross-sectional study of its quantitative profile between 10 and 40 weeks gestation was undertaken. Though there was a wide scatter of values, the rise in the average activity was continuous and highly significant. The flavoprotein inhibitor, quinacrin, inhibited the enzyme activity, while the pyridoxal phosphate inhibitor, isoniazid, had no significant inhibitory effect suggesting that the enzyme is of tissue origin. The possible role of polyamines and their oxidation in physiological immunoregulation is discussed.Keywords
This publication has 14 references indexed in Scilit:
- Polyamine conjugates and total polyamine concentrations in human amniotic fluidClinica Chimica Acta; International Journal of Clinical Chemistry, 1979
- What do the polyamines do?Nature, 1978
- Polyamines in rapid growth and cancerBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1978
- POLYAMINE INTERACTION WITH PREGNANCY SERUM IN SUPPRESSION OF LYMPHOCYTE TRANSFORMATIONThe Lancet, 1978
- Identification of a thymic inhibitor (‘chalone’) of lymphocyte transformation as a spermine complexNature, 1977
- Synthetic polyamines added to cultures containing bovine sera reversibly inhibit in vitro parameters of immunityNature, 1977
- Oxidation of spermidine and spermine in rat liver: purification and properties of polyamine oxidaseBiochemistry, 1977
- 1,4-Diaminobutane (Putrescine), Spermidine, and SpermineAnnual Review of Biochemistry, 1976
- Amine synthesis in rapidly growing tissues: ornithine decarboxylase activity in regenerating rat liver, chick embryo, and various tumors.Proceedings of the National Academy of Sciences, 1968
- Spermidine and Spermine in Rat Tissues at Different AgesActa Physiologica Scandinavica, 1964