THEORY OF REVERSIBLE DENATURATION OF GLOBULAR PROTEINS
- 1 July 1975
- journal article
- Published by Wiley in International Journal of Peptide and Protein Research
- Vol. 7 (4), 313-323
- https://doi.org/10.1111/j.1399-3011.1975.tb02446.x
Abstract
A theoretical method is developed by which the character of the process of protein denaturation (e.g., whether or not it is of the all-or-none type) can be discussed in terms of conformation of native proteins and the forces stabilizing it. An important role is played by a quantity S(H): entropy of a protein molecule in solution in the conformational states with a given value of enthalpy H. It is demonstrated that the all-or-none type denaturation of proteins is a rather direct consequence of the globularity and specificity of the native conformations. Denaturations with significant intermediate states are discussed. Denaturations induced by added denaturants are also discussed.Keywords
This publication has 1 reference indexed in Scilit:
- Analysis of the Contribution of Internal Vibrations to the Statistical Weights of Equilibrium Conformations of MacromoleculesThe Journal of Chemical Physics, 1969