NEUTRALIZATION OF INFUSED ACID BY NEPHRECTOMIZED DOGS 1

Abstract

Severe metabolic acidosis was produced in nephrectomized dogs by infusing 9 to 10 m[image]/kg of HC1 over a 2 hour period. Changes in total extracellular Na, K, bicarbonate and Cl were calculated from plasma concentrations and changes in the radiosulfate volume of distribution. Approximately 40% of the infused acid was apparently neutralized by extracellular bicarbonate, 10% by erythrocyte buffers, and 50% by diffusion of Na and K into extracellular fluid. Exchange of extracellular H ions for intra-cellular Na and K-ions is suggested to account for the increment in extracellular Na, K- and water.