Renal and pressor action of angiotensin in the normal dog
- 31 May 1965
- journal article
- research article
- Published by American Physiological Society in American Journal of Physiology-Legacy Content
- Vol. 208 (6), 1093-1099
- https://doi.org/10.1152/ajplegacy.1965.208.6.1093
Abstract
The renal and pressor actions of angiotensin in relation to dose were studied in unanesthetized dogs. Low doses caused depression of urine flow, electrolyte excretion, glomerular filtration rate (GFR), and Cpah. With higher doses, the initial depression of urine flow, GFR, and Cpah was greater, but subsequently these functions rose toward control values. In fact, diuresis occurred, accompanied by natriuresis, chloruresis, and kaliuresis. The natriuresis occurred at a time when GFR was significantly depressed. In longer experiments at high doses it was found that the natriuresis declined after 50 min despite continued angiotensin infusion; however, potassium excretion gradually increased throughout. These results help clarify the confusing literature regarding the effects of angiotensin on renal function in dogs and also support the hypothesis that angiotensin can block tubular sodium reabsorption. The pressor response was found to be proportional to the logarithm of the dose of angiotensin. It was also inversely related to the control blood pressure of the dog.Keywords
This publication has 25 references indexed in Scilit:
- THE EFFECTS OF INTRAVENOUS INFUSIONS OF VALINE-5 ANGIOTENSIN II AND OTHER PRESSOR AGENTS ON URINARY ELECTROLYTES AND CORTICOSTEROIDS, INCLUDING ALDOSTERONE*JCI Insight, 1961
- THE EFFECTS OF SYNTHETIC ANGIOTENSIN AND NORADRENALINE ON BLOOD PRESSURE AND RENAL FUNCTIONHeart, 1961
- THE PHYSIOLOGICAL BASIS FOR A METHOD OF ASSAYING ALDOSTERONE IN EXTRACTS OF HUMAN URINEJCI Insight, 1955
- THE EFFECT OF ADRENAL STEROIDS ON RENAL MECHANISMS OF ELECTROLYTE EXCRETIONAnnals of the New York Academy of Sciences, 1955
- Studies of the Renal CirculationCirculation, 1950
- HYPERTENSION PRODUCED IN THE RABBIT BY LONG CONTINUED INFUSIONS OF RENIN1950
- INFLUENCE OF GRADED ARTERIAL PRESSURE DECREMENT ON RENAL CLEARANCE OF CREATININE, P-AMINOHIPPURATE AND SODIUMAmerican Journal of Physiology-Legacy Content, 1949
- The nature of the action of renin and hypertensin on renal function in the rabbitThe Journal of Physiology, 1949
- The effect of renin on urine formation1The Journal of Physiology, 1940
- THE EFFECTS OF A PEESSOE SUBSTANCE OBTAINED FROM THE KIDNEYS ON THE RENAL CIRCULATION OF RATS AND DOGSThe American Journal of the Medical Sciences, 1938