PERCUTANEOUS-ABSORPTION OF C-14-LABELED INSECT REPELLENTS IN HAIRLESS DOGS
- 1 January 1980
- journal article
- research article
- Vol. 4 (1), 249-256
Abstract
The percutaneous penetration of 3 insect repellents was determined in hairless dogs. Each compound was administered i.v. and topically to 3 dogs. Urine, feces and blood samples were assayed for radioactivity by scintillation counting. The percent penetration for N,N-diethyl-m-toluamide (m-deet, the most widely used insect repellent), its isomer N,N-diethyl-p-toluamide and 2-ethyl-1,3-hexanediol were 7.9, 7.6 and 10.3%, respectively. The results for m-deet penetration in the hairless dog are compatible to those in man.This publication has 2 references indexed in Scilit:
- Distribution and Fate of the Insect Repellent 14C‐N, N‐diethyl‐m‐toluamide in the Animal Body. II. Distribution and Excretion after Cutaneous ApplicationActa Pharmacologica et Toxicologica, 1977
- Penetration of 14C Hydrocortisone Through Normal SkinArchives of Dermatology, 1965