A guide to prognosis in stress diseases has been devised on the basis of experience in the treatment of 739 patients in the Medicine A clinic of the New York Hospital. Its validity has been tested in three selected groups of patients with essential hypertension, migraine, and asthma. An earlier report of the experience of this clinic 1 emphasized a description of the general methods of treatment used, an appraisal of the effectiveness of each, and an estimation of the important prognostic factors. In the present report a more systematic appraisal of prognosis is offered in the form of a score sheet on which a patient can be rated after the first three or four visits to the physician. Most of the patients were seen at approximately weekly intervals during the first month of attendance at the clinic and at biweekly or monthly intervals thereafter. The average number of visits