Plasma Somatostatin-Like Immunoreactivity in Chemically Sympathectomized Dogs

Abstract

The present study was designed to determine the role of the adrenergic nerves upon basal and postprandial gastric and pancreatic SLI [somatostatin-like immunoreactivity] release. In 19 chemically sympathectomized [6-hydroxydopamine] dogs peripheral venous plasma SLI levels in the basal and postprandial state were significantly below those of 30 controls for the first 135 min after the ingestion of a fat-protein meal. To determine the origin of this reduction, the SLI release from fundus, antrum and pancreas was studied in anesthetized dogs during the gastric phase of a meal at either pH 7 or pH 2. In response to a liver meal at pH 7 fundic, antral and pancreatic vein SLI levels were below the control and the rise in inferior vena cava SLI was abolished. In response to a liver meal at pH 2, the rise in antral and pancreatic vein SLI was clearly reduced in the sympathectomized dogs, while the decrease in fundic SLI was not influenced. The data demonstrate that adrenergic innervation plays a role in basal and postprandial SLI release from the stomach and pancreas.