GABAergic inputs modulate effects of interleukin-1β on supraoptic neurones in vitro

Abstract

WE have previously reported that human recombinant interleukin (IL)-1β depolarizes membrane potentials in most rat hypothalamic supraoptic (SON) neurones in vitro. In the present study intracellular recordings have been made to examine contributions of local GABAergic interneurones to the effects of IL-1β on SON neurones in rat brain slice preparations. The results suggest that local GABAergic inputs modulate IL-induced excitatory responses, and are involved in tonic inhibition of SON neuronal activities.