Identification of Pyrilamine Metabolites by Ammonia Chemical Ionization Mass Spectrometry

Abstract

The ammonia chemical ionization mass spectrometric analysis of pyrilamine, the N-oxide of pyrilamine, and related compounds is described. The use of ammonia as the reagent gas produced excellent [M + H]⁺ ions for these compounds. The suitability of this method for the analysis of two rat urinary metabolites of pyrilamine is demonstrated.