An antifungal factor in human serum
- 1 January 1966
- journal article
- Published by Oxford University Press (OUP) in Medical Mycology
- Vol. 4 (3), 179-186
- https://doi.org/10.1080/00362176685190411
Abstract
The amount of growth of Rhizopus rhizopodiformis on culture media containing varying proportions of human serum was determined. It was found that normal serum inhibited growth at concentrations above 20% and that inhibition was increased proportionally with increasing concentrations of serum. Dialysis of normal serum against saline removed inhibition in high serum concentrations. Immunoelectrophoretic studies showed that dialysis of normal serum denatured several proteins in the β-1 zone. It also slightly denatured the slow-moving lipoprotein fraction. The inhibitory effect was decreased in sera from patients with ketoacidotic diabetes, chronic leukemia and cirrhosis.Keywords
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