Chlormethiazole, sleep, and drug withdrawal
- 1 August 1972
- journal article
- research article
- Published by Cambridge University Press (CUP) in Psychological Medicine
- Vol. 2 (3), 239-247
- https://doi.org/10.1017/s0033291700042537
Abstract
Synopsis: The hypothesis that drug withdrawal delirium was related to a gross disturbance of sleep and a marked excess of REM sleep, suggested that drugs used to treat delirium should depress REM sleep. Chlormethiazole in doses over l g was found to be effective in depressing REM sleep and in blocking the REM sleep rebound when sodium amylobarbitone (400 mg) was stopped abruptly.Keywords
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