Preliminary Anthelmintic Studies with Nematospiroides dubius in Mice

Abstract

Compound 1871 has been found to exhibit a high order of activity against N. dubius. The efficacy of this compound has been based on a critical testing method in which worm elimination has been the sole criterion for measuring activity. Doses as low as 12.5 mg/kg are capable of effective activity. Established anthelmintics are relatively ineffective against N. dubius in that large multiple doses are required to produce measurable activity against an inoculum of 40 larvae/mouse. The size of the inoculum does not appreciably influence the activity of compound 1871.