Slow Elimination of Urethan in Relation to its High Garcinogenicity in Newborn Mice.
- 1 June 1964
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 116 (2), 265-268
- https://doi.org/10.3181/00379727-116-29220
Abstract
Summary Urethan was found to be eliminated from newborn SWR mice at about one-tenth of the rate found in adults, when injected at a dose of 0.5 mg/g body weight. The longer time during which urethan remains in the body may explain the greater carcinogenic action in newborn mice as compared with adults.Keywords
This publication has 12 references indexed in Scilit:
- Lung Carcinogenesis by Urethane in Newborn, Suckling, and Adult Swiss MiceBritish Journal of Cancer, 1962
- The effects of carcinogenic chemicals in newborn miceCancer, 1961
- Possible Two-Stage Mechanism in Experimental LeukemogenesisScience, 1960
- A STUDY OF THE RELATIONSHIP BETWEEN THE RATE OF ETHYL CARBAMATE (URETHAN) CATABOLISM AND URETHAN CARCINOGENESIS1960
- CHROMATOGRAPHIC STUDIES IN RELATION TO ETHYL CARBAMATE (URETHAN) CARCINOGENESIS USING C-14-LABELED COMPOUNDS1960
- DISTRIBUTION OF C14-LABELED URETHANS IN TISSUES OF THE MOUSE AND SUBCELLULAR LOCALIZATION IN LUNG AND LIVER1958
- URETHAN AND LEUKEMOGENESIS IN MICE1958
- The Transplacental Effect of Urethan on Lung Tumorigenesis in Mice2JNCI Journal of the National Cancer Institute, 1952
- CARBAMATES IN THE CHEMOTHERAPY OF LEUCEMIA .7. THE RATE OF CATABOLISM OF URETHANE IN NORMAL AND NEOPLASTIC MICE1949
- CARBAMATES IN THE CHEMOTHERAPY OF LEUCEMIA .4. THE DISTRIBUTION OF RADIOACTIVITY IN TISSUES OF MICE FOLLOWING INJECTION OF CARBONYL-LABELED URETHANE1949