STUDIES ON THE PATHOGENESIS OF FEVER
Open Access
- 1 December 1957
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 106 (6), 787-809
- https://doi.org/10.1084/jem.106.6.787
Abstract
The "endogenous serum pyrogen" that appears in the circulating blood after a single intravenous injection of endotoxin does not produce leukopenia in normal animals, fails to provoke the local Shwartzman reaction, and elicits no "tolerance" when injected daily. Suppression of the febrile response to endotoxin by prednisone does not prevent the appearance of pyrogen in the blood.Keywords
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