Serologic characteristics of a human rotavirus isolate, AU-1, which has a “long” RNA pattern and subgroup I specificity

Abstract

An unusual human rotavirus (HRV) isolate, designated AU‐1, has a “long” RNA electrophoretic pattern and subgroup I specificity, in contrast to properties common to HRVs previously isolated. Hemagglutination activity of the AU‐1 strain was demonstrated using erythrocytes of 1‐day‐old chicken. Neutralization assays revealed that the AU‐1 strain was crossneutralized by hyperimmune antisera against the MO strain (serotype 3). However, antiserum directed against a reassortant in which the gene for Vp7 was replaced by the corresponding AU‐1 gene neutralized the AU‐1 strain to a significantly higher titer than the MO strain.