Introduction In 1940, Kasabach et al. first reported the association of hemangioma with thrombocytopenic purpura. This observation has since been confirmed and reported in an additional 19 patients. Dargeon1and Petit2have recently reviewed a majority of these cases. The purpose of this report is to present a combination of giant hemangioendothelioma with thrombocytopenia in a Negro female infant. Report of a Case This 2-month-old Negro girl was admitted to the USAF Hospital at Lackland Air Force Base, Texas, August 20, 1958. Her mother's pregnancy was uncomplicated; she was delivered spontaneously at term. The birth weight was 7 lb. 1 oz. On physical examination a "welt" about 4 cm. * 2 mm., with a ridge down the center, was noted in the left lower abdominal quadrant. The infant became quite irritable when the lesion was palpated. At two weeks of age, the area had enlarged to 6 *