The Bovine Pulmonary Inflammatory Response: Adjuvant Pneumonitis in Calves
- 1 September 1982
- journal article
- Published by SAGE Publications in Veterinary Pathology
- Vol. 19 (5), 506-520
- https://doi.org/10.1177/030098588201900506
Abstract
Twenty one- to two-month-old Holstein, Angus, or Holstein-Angus crossbred calves were given intravenous complete Freund's adjuvant and their lungs were examined at 24 hours to 30 days post-injection. Two calves given intravenous saline served as normal controls. The evolving pulmonary inflammatory response was characterized initially by multifocal vasculitis and acute multifocal exudative pneumonitis which progressed to a granulomatous interstitial pneumonitis by seven days post-injection. Discrete granulomas characterized the lesions in the lungs and lymph nodes at 30 days post-injection, and granulomas also were seen in liver, kidney, and spleen. Clinically, the calves were tachypneic and pyrexic during the first week post-injection. Four calves developed acute pulmonary edema and died during, or shortly after, administration of the adjuvant. This model of experimental pneumonia in calves is similar to complete Freund's adjuvant-induced experimental pneumonia in other species. It is reproducible and predictable in its course of development and resolution, and provides a useful model for studying basic mechanisms of pulmonary inflammatory injury and repair in the bovine lung.Keywords
This publication has 17 references indexed in Scilit:
- Toxicity of Mold-Damaged SweetpotatoesNutrition Reviews, 2009
- Effects of 4-Ipomeanol, a Product from Mold-Damaged Sweet Potatoes, on the Bovine LungVeterinary Pathology, 1978
- Injury and repair of the lung: Response to intravenous freund's adjuvantThe Journal of Pathology, 1978
- Proliferation of type II alveolar cells: A review of common responses in toxic lung injuryToxicology, 1976
- Fog fever in cattle: pathologyPublished by Wiley ,1974
- ADJUVANTSAnnals of the New York Academy of Sciences, 1974
- The origin and turnover of alveolar macrophages in experimental pneumoniaThe Journal of Pathology, 1973
- A bovine disease similar to farmer's lung: extrinsic allergic alveolitisPublished by Wiley ,1971
- Experimental induction of an acute respiratory syndrome in cattle resembling bovine pulmonary emphysemaPublished by Wiley ,1967
- Effect of Emulsion Injections in the RabbitInternational Archives of Allergy and Immunology, 1965