CD studies on the conformation of some deoxyoligonucleotides containing adenine and thymine residues
- 1 January 1974
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 1 (8), 1017-1030
- https://doi.org/10.1093/nar/1.8.1017
Abstract
CD studies of the deoxyoligomer series d(pT)(n) and d(pA)(n) show increasing CD maxima for oligo (dT)'s with chain length variation from two to seven, while oligo (dA)'s exhibit a decreasing CD maximum. Concentrated solutions of NaClO(4) cause a decrease in the CD of longer oligo (dT)'s towards the CD of d(pT)(2) which is different from oligo dA's. Probably base-sugar interactions are important in the observed conformational effects. The chemically synthesized oligomers dpApApTpT and dpTpApTpA show deviations in their CD spectra which reflect a dominating conformational effect of d(pA)(2) in the former but not in the alternating isomer.Keywords
This publication has 16 references indexed in Scilit:
- Direct Evidence of the C-Like Form of Sodium DeoxyribonucleateProceedings of the National Academy of Sciences, 1973
- Conformation and reactivity of DNABiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1973
- Oligonucleotides. 2. Conformation of oligoinosinates. Chain-length dependence and comparison to other oligonucleotidesBiochemistry, 1972
- Circular dichroism of DNA: Temperature and salt dependenceBiopolymers, 1972
- Optical activity of flow-oriented deoxyribonucleic acidJournal of the American Chemical Society, 1971
- Helix formation by d(TA) oligomers: III. Electrostatic effectsJournal of Molecular Biology, 1970
- Oligonucleotide interactions. III. Circular dichroism studies of the conformation of deoxyoligonucleolidesBiopolymers, 1970
- Optical properties and conformation of pyrimidine nucleosides in solutionBiochemical and Biophysical Research Communications, 1970
- Cooperative interactions in single‐strand oligomers of adenylic acidBiopolymers, 1966
- Studies on Polynucleotides. XLIV.1 The Synthesis of Dodecanucleotides Containing the Repeating Trinucleotide Sequence Thymidylyl- (3'→5') -thymidylyl- (3'→5') -deoxycytidine2,3Journal of the American Chemical Society, 1965