Phagocytosis of Light- and Dark-Adapted Rod Outer Segments by Cultured Pigment Epithelium
- 3 November 1978
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 202 (4367), 526-528
- https://doi.org/10.1126/science.568310
Abstract
Pigment epithelial cells in culture retain their ability to phagocytize rod outer segments. These cells phagocytize rod outer segments isolated from light-adapted rats, or from dark-adapted rats killed after the time at which the lights would normally be turned on. However, they phagocytize for fewer rod outer segments prepared in the dark from the retinas of rats killed before the onset of the normal light cycle. Phagocytosis of dark rod outer segments is variable, but that of light outer segments is reproducible. It is postulated that the effect of light is to synchronize the chemical events that occur at the surface of the rods to prepare them for phagocytosis. These processes also occur in the dark, but more slowly and irregularly than in the light.This publication has 13 references indexed in Scilit:
- Turnover of rod photoreceptor outer segments. II. Membrane addition and loss in relationship to light.The Journal of cell biology, 1977
- Defective Phagocytosis of Isolated Rod Outer Segments by RCS Rat Retinal Pigment Epithelium in CultureScience, 1977
- Rod Outer Segment Disk Shedding in Rat Retina: Relationship to Cyclic LightingScience, 1976
- Photoreceptor Shedding Is Initiated by Light in the Frog RetinaScience, 1976
- The effect of light on the quantity of phagosomes in the pigment epitheliumExperimental Eye Research, 1976
- Rhodopsin as a glycoprotein: a possible role for the oligosaccharide in phagocytosisExperimental Eye Research, 1976
- PhagocytosisNew England Journal of Medicine, 1974
- Shedding of discs from rod outer segments in the rhesus monkeyJournal of Ultrastructure Research, 1971
- PARTICIPATION OF THE RETINAL PIGMENT EPITHELIUM IN THE ROD OUTER SEGMENT RENEWAL PROCESSThe Journal of cell biology, 1969
- THE RENEWAL OF PHOTORECEPTOR CELL OUTER SEGMENTSThe Journal of cell biology, 1967