Calcium pentosan polysulfate is a multifaceted exosite inhibitor of aggrecanases
Open Access
- 30 June 2008
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 22 (10), 3515-3524
- https://doi.org/10.1096/fj.08-112680
Abstract
Degradation of the cartilage proteoglycan aggrecan is a key early event in the development of osteoarthritis. Adamalysin with thrombospondin motifs (ADAMTS) −4 and ADAMTS‐5 are considered to be the m...Keywords
Funding Information
- National Institutes of Health (AR40994)
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