Complete or partial trisomy for the long arm of chromosome 1 in patients with various hematologic malignancies
- 1 April 1983
- journal article
- research article
- Published by Springer Nature in Human Genetics
- Vol. 63 (2), 107-112
- https://doi.org/10.1007/bf00291527
Abstract
This study contains data obtained from a cytogenetic investigation of six patients with acute and chronic leukaemia. The karyotypes of bone marrow or blood cells of these patients showed a partial or complete trisomy for the long arm of chromosome 1. Three observations revealed a pronounced resistance of cell clones with 1q+towards cytostatic therapy, and a comparatively short life span of patients after detection of 1q+. The importance of these changes for the role of some chromosomes and chromosome loci in leukaemogenesis is discussed.Keywords
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