Pharmacological evidence that central .ALPHA.2-adrenoceptors are involved in cardiovascular responses to intravenously injected enkephalins in anesthetized dogs.

Abstract

In anesthetized dogs, i.v. injections of 30 .mu.g/kg of leucine- and methionine-enkephalin (L- and M-enk, respectively) produced a significant reduction of mean blood pressure (MBP) and heart rate (HR). The peak decreases in MBP and HR occurred within 1 min after injection and recoveries to pre-injection levels within 3 min. The depressor responses to both L-enk and M-enk were abolished by intracisternal pretreatment with yohimbine (0.5 mg/kg) but not with prazosin (0.1 mg/kg). Pretreatment with either drug did not alter the bradycardia. All cardiovascular effects of both L-enk and M-enk were prevented by i.v. pretreatment with naloxone (2 mg/kg). Apparently, central .alpha.2-adrenoceptors may participate in the central actions of enkephalins on blood pressure regulation. HR responses to enkephalins may be elicited by a different mechanism.