Combination Chemotherapy Followed by Skin Grafts in the Management of Locally Advanced Breast Cancer

Abstract

A combined modality approach to the treatment of locally advanced, ulcerating carcinoma of the breast was discussed. The beneficial effects of combination chemotherapy were amplified by split thickness skin grafts at the site of a large skin deficit, resulting in successful wound palliation. Criteria for assessing likelihood of graft acceptance by an ulcerating wound in the presence of local neoplastic disease were emphasized.