Ubiquitylation and cell signaling
Top Cited Papers
Open Access
- 8 September 2005
- journal article
- review article
- Published by Springer Nature in The EMBO Journal
- Vol. 24 (19), 3353-3359
- https://doi.org/10.1038/sj.emboj.7600808
Abstract
Ubiquitylation is an emerging mechanism implicated in a variety of nonproteolytic cellular functions. The attachment of a single ubiquitin (Ub) or poly‐Ub (lysine 63) chains to proteins control gene transcription, DNA repair and replication, intracellular trafficking and virus budding. In these processes, protein ubiquitylation exhibits inducibility, reversibility and recognition by specialized domains, features similar to protein phosphorylation, which enable Ub to act as a signaling device. Here, we highlight several recent examples on how Ub regulates signaling and how signaling regulates ubiquitylation during physiological and pathological cellular processes.Keywords
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