Effects of Total-Body Irradiation on the Production of Antibody in Man

Abstract

THE numerous studies of the effects of whole-body irradiation on the immunologic response of animals have recently been reviewed,¹ and attention has been called to the various factors involved in suppressing or delaying the production of antibody by this agent. These include the following: the amounts of antigen and radiation used; the relation of the time of administration of antigen to the administration of radiation; the type and rate of disappearance of the antigen; the type of response tested — that is, primary or secondary; and perhaps variation in the reaction of different species. In general, the anamnestic response is . . .