Characteristics of histamine release evoked by acetylcholine in isolated rat mast cells.
- 1 April 1980
- journal article
- research article
- Published by Wiley in The Journal of Physiology
- Vol. 301 (1), 281-293
- https://doi.org/10.1113/jphysiol.1980.sp013205
Abstract
Histamine secretion from rat mast cells occurs in the presence of nanomolar concentrations of acetylcholine. Intact glycolytic and oxidative metabolism is required for the acetylcholine-induced histamine secretion. Removal of extracellular glucose, hypoxia, cyanide and monoiodoacetate almost completely inhibit the secretion. The secretion of histamine is dependent on the extracellular H ion concentration and is blocked when the cells are exposed to Na-deficient media. The order of potency of cholinergic agonists in evoking the secretion of histamine is oxotremorine > acetylcholine > choline > carbamylcholine > nicotine. Atropine competitively blocks the acetylcholine-induced histamine secretion, indicating the presence of cholinergic muscarinic receptors on mast cells. Dibutyryl cyclic AMP and adrenaline [epinephrine] inhibit the acetylcholine-induced histamine secretion, indicating a regulatory function afforded by cyclic nucleotides in the cholinergic histamine release.This publication has 51 references indexed in Scilit:
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