OBSERVATIONS ON CREATININE AND UREA CLEARANCES, ON RESPONSES TO WATER INGESTION AND ON CONCENTRATING POWER OF KIDNEYS IN NORMAL, DIABETES INSIPIDUS AND HYPOPHYSECTOMIZED DOGS

Abstract

Hypophysectomized or diabetes insipidus (DI) clogs show normal time relations of blood dilution and. urine output, responses to ingestion of 3% body wt. of water. Creatinine clearance is at first normal in exptl. DI, may fall as low as 50% of normal some time after onset of permanent phase and then gradually returns to normal. Urea clearance falls much less than creatinine and may not fall at all. Creatinine clearance is slightly and urea considerably increased by ant. lobe administration. After 24 hrs. of water deprivation the ability of hypophysectomized (without polyuria) and of DI dogs to concentrate urine is impaired about 50% with urea, 25% with creatinine and unchanged with chloride. Hypophysectomized dogs tolerate water deprivation normally but DI cannot. Dogs with DI may show temporary phases of normal rates of urine output.