Transactivation joins multiple tracks to the ERK/MAPK cascade
- 1 August 2003
- journal article
- Published by Springer Nature in Nature Reviews Molecular Cell Biology
- Vol. 4 (8), 651-657
- https://doi.org/10.1038/nrm1173
Abstract
Many agonists of G-protein-coupled receptors (GPCRs) can stimulate receptor tyrosine kinases and the extracellular signal-regulated kinase (ERK)/mitogen-activated protein kinase (MAPK) pathway. A 'transactivation' mechanism, which links these events in one signalling chain, inspired many researchers, but inevitably raised new questions. A 'multi-track' model for GPCR signalling to the ERK/MAPK pathway might resolve some of the puzzles in the transactivation field.Keywords
This publication has 61 references indexed in Scilit:
- Seven-transmembrane receptorsNature Reviews Molecular Cell Biology, 2002
- Integration of Signals from Receptor Tyrosine Kinases and G Protein-Coupled ReceptorsNeurosignals, 2002
- Ras-MAP kinase signaling by lysophosphatidic acid and other G protein-coupled receptor agonistsOncogene, 2001
- New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascadesOncogene, 2001
- Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmissionOncogene, 2001
- Cell Signaling by Receptor Tyrosine KinasesCell, 2000
- Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled ReceptorsScience's STKE, 2000
- EGF Receptor Transactivation Mediated by the Proteolytic Production of EGF-like AgonistsScience's STKE, 2000
- EGF receptor phosphorylation is affected by ionizing radiationBiochimica et Biophysica Acta (BBA) - Molecular Cell Research, 1997
- Role of transactivation of the EGF receptor in signalling by G-protein-coupled receptorsNature, 1996