Inhibition of N-nitrosobenzylmethylamine-induced esophageal tumorigenesis in rats by ellagic acid
- 1 January 1990
- journal article
- research article
- Published by Oxford University Press (OUP) in Carcinogenesis: Integrative Cancer Research
- Vol. 11 (1), 55-61
- https://doi.org/10.1093/carcin/11.1.55
Abstract
Ln this report, we describe the ability of ellagic acid (EA), a phenolic compound present in a number of fruits and nuts, to inhibit N-nitrosobenzylmethylamnine (NEMA) twnorigenesis in the rat esophagus. When administered in a semi-purified diet at concentrations of 0.4 and 4 glkg, EA produced a significant (21–55%) decrease in the average number of NBMA-induced esophageal tumors after 20 and 27 weeks of the bioassay. FA exhibited inhibitory effects toward preneoplastic lesions as well as neoplastic lesions. Tumors were not observed in vehicle-control rats or in rats that received EA alone.This publication has 20 references indexed in Scilit:
- INHIBITION OF BENZO(A)PYRENE AND BENZO(A)PYRENE-TRANS-7,8-DIOL METABOLISM AND DNA-BINDING IN MOUSE LUNG EXPLANTS BY ELLAGIC ACID1985
- Inhibition of the mutagenicity of bay-region diol epoxides of polycyclic aromatic hydrocarbons by naturally occurring plant phenols: Exceptional activity of ellagic acidProceedings of the National Academy of Sciences, 1982
- Esophageal Carcinogenesis in F344 Rats by Nitrosomethylethylamines Substituted in the Ethyl Group23JNCI Journal of the National Cancer Institute, 1982
- METABOLISM OF N-NITROSAMINES BY CULTURED HUMAN AND RAT ESOPHAGUS1982
- The metabolism of ellagic acid in the ratXenobiotica, 1980
- Intake of Volatile Nitrosamines From Consumption of Alcohols2JNCI Journal of the National Cancer Institute, 1979
- Oesophageal cancer and alcohol consumption; importance of type of beverageInternational Journal of Cancer, 1979
- STUDIES ON THE ESOPHAGUS .3. CARCINOGENESIS IN RAT ESOPHAGUS BY INTRA-PERITONEAL INJECTION OF DIFFERENT DOSES OF METHYL-NORMAL-AMYLNITROSAMINE1979
- Pathology of Esophageal Neoplasms and Associated Proliferative Lesions Induced in Rats by N-Methyl-N-benzylnitrosamineJNCI Journal of the National Cancer Institute, 1978
- A study of etiological factors in cancer of the esophagusCancer, 1961