INHIBITION BY HISTAMINASE OF GASTRIC SECRETION IN DOGS

Abstract

A prepn. of histaminase made from hog renal cortex and containing about 1.2 Winthrop units of histaminase per mg. of dry powder was tested for its gastric secretory depressant action. Twenty U. kg. body wt., given intraven., markedly inhibited the gastric secretory response to 0.0125 mg. of histamine dihydrochloride given subcut. every 10 min. in dogs with pouches of the entire stomach. No toxic side reactions occurred. The secretory response to food and to parasympathomimetic drugs was also inhibited by this histaminase prepn. A decision cannot yet be made as to whether the inhibition of gastric secretion is due to the histaminase or to some other constituent of these extracts.