Genetics of post‐traumatic stress disorder: Informing clinical conceptualizations and promoting future research
- 22 April 2008
- journal article
- review article
- Published by Wiley in American Journal Of Medical Genetics Part C-Seminars In Medical Genetics
- Vol. 148C (2), 127-132
- https://doi.org/10.1002/ajmg.c.30169
Abstract
The purpose of this article is to provide an overview of genetic research involving post-traumatic stress disorder (PTSD). First, we summarize evidence for genetic influences on PTSD from family investigations. Second, we discuss the distinct contributions to our understanding of the genetics of PTSD permitted by twin studies. Finally, we summarize findings from molecular genetic studies, which have the potential to inform our understanding of underlying biological mechanisms for the development of PTSD.Keywords
This publication has 50 references indexed in Scilit:
- Gene-environment interaction in posttraumatic stress disorderArchiv Fur Psychiatrie Und Nervenkrankheiten, 2008
- Differential Etiology of Posttraumatic Stress Disorder with Conduct Disorder and Major Depression in Male VeteransBiological Psychiatry, 2007
- Common genetic liability to major depression and posttraumatic stress disorder in menJournal of Affective Disorders, 2007
- Early childhood factors associated with the development of post-traumatic stress disorder: results from a longitudinal birth cohortPsychological Medicine, 2006
- Clarifying the Origin of Biological Abnormalities in PTSD Through the Study of Identical Twins Discordant for Combat ExposureAnnals of the New York Academy of Sciences, 2006
- Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependenceAmerican Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 2006
- Neuropsychiatric Associations of Apolipoprotein E Alleles in Subjects With Combat-Related Posttraumatic Stress DisorderThe Journal of Neuropsychiatry and Clinical Neurosciences, 2005
- Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured childrenMolecular Psychiatry, 2005
- Apolipoprotein E ∈4 Allele Affects the Relationship between Stress and Depression in Caregivers of Patients with Alzheimer's DiseaseJournal of Geriatric Psychiatry and Neurology, 2001
- Do genes influence exposure to trauma? A twin study of combatAmerican Journal of Medical Genetics, 1993