Relationship of dietary intake to concentration of dieldrin and endrin in dogs

Abstract

The method utilized in this investigation was simple, rapid, and quantitative for the measurement of dieldrin and endrin in the blood and tissues of dogs and mice and should be useful in the diagnosis of unknown toxicity syndromes in human beings. Levels of dieldrin in the blood were indicative of the concentrations of these agents in tissues and vital organs; however, there was no correlation between levels of endrin in blood and tissues other than fat.Feeding equal quantities of dieldrin and endrin resulted in approximately equal concentrations in blood after 48 hours. Thereafter, dieldrin accumulated rapidly as feeding was continued, whereas endrin did not. These data indicate different modes in the metabolism of these stereoisomers in dogs.