Increasing diversity of HIV-1M serotypes in French blood donors over a 10-year period (1985–1995)
- 11 October 1997
- journal article
- research article
- Published by Wolters Kluwer Health in AIDS
- Vol. 11 (12), 1503-1508
- https://doi.org/10.1097/00002030-199712000-00015
Abstract
Objective: Phylogenetic analysis of gene sequences of HIV-1 has led to the classification of isolates into a major group (M) of viruses, itself divided into subtypes (A to I), and a minor group (O) of rare isolates. Subtype B viruses are the most prevalent in Western countries but little is known about the dynamics of diffusion of the other subtypes in these regions. The prevalence of B subtypes and non-B subtypes in French blood donors between 1985 and 1995 was evaluated. Methods: A retrospective study was conducted in 490 blood donors, identified as positive for antibody to HIV-1, by twelve French blood banks between 1985 and 1995. Serological subtyping was performed with a subtype-specific enzyme immunoassay, the reliability for genotyping of which has been demonstrated previously. Results: Of 450 typable samples, 48 (10.7%) were non-B subtypes. Non-B reactive samples were found in all of the regions. An increasing prevalence of individuals infected by non-B viruses was observed, from approximately 4% in the early period to more than 20% in 1994–1995 (P = 0.0004). Non-B viruses did not appear to be restricted to patients with direct or indirect epidemiological links to non-European populations. Conclusion: We observed an increasing diversity of HIV-1 strains in the population of blood donors residing in France. This stresses the necessity to broaden the surveillance of HIV-1 diversity in order to improve measures to prevent HIV-1 infections.Keywords
This publication has 24 references indexed in Scilit:
- Survival with AIDS in IrelandAIDS, 1997
- Lack of screening test sensitivity during HIV-1 non-subtype B seroconversionsAIDS, 1996
- HIV Type 1 Thai Subtype E Is Predominant in South VietnamAIDS Research and Human Retroviruses, 1996
- The Emerging Genetic Diversity of HIVJAMA, 1996
- Genetic diversity and HIV detection by polymerase chain reactionThe Lancet, 1995
- V3 Region Polymorphisms in HIV-1 from Brazil: Prevalence of Subtype B Strains Divergent from North American/European Prototype and Detection of Subtype FAIDS Research and Human Retroviruses, 1994
- Characterization of Human Immunodeficiency Virus Type 1 Isolates from Children in Romania: Identification of a New Envelope SubtypeThe Journal of Infectious Diseases, 1994
- Identification of Human Immunodeficiency Virus Type 1 Subtypes and Their Distribution in the Commonwealth of Independent States (Former Soviet Union) by Serologic V3 Peptide-Binding Assays and V3 Sequence AnalysisThe Journal of Infectious Diseases, 1993
- Greater diversity of the HIV-1 V3 neutralization domain in Tanzania compared with The NetherlandsAIDS, 1993
- Genetic Variants of HIV-1 in ThailandAIDS Research and Human Retroviruses, 1992