Tensile forces enhance prostaglandin E synthesis in osteoblastic cells grown on collagen ribbons
- 1 March 1984
- journal article
- Published by Springer Nature in Calcified Tissue International
- Vol. 36 (S1), S67-S71
- https://doi.org/10.1007/bf02406136
Abstract
An experimental system has been developed to examine the prostaglandin (PG) production induced by tensile mechanical forces in bone cells cultured on collagen ribbons. Fetal rat calvaria cells (osteoblast-enriched) were grown on collagen ribbons. The collagen ribbons were stretched under culture conditions in a machine that recorded force and displacement. Repeated stretching of the collagen ribbons (8 times, 5–10%, over 2 hours) increased the rate of prostaglandin synthesis approximately 3.5-fold over that of cells on nonstretched ribbons. This system should provide a suitable method to quantitatively study the effect of mechanical forces on various parameters of PG synthesis.Keywords
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