A randomized trial of 13-Cis retinoic acid in children with advanced neuroblastoma after high-dose therapy
Open Access
- 1 November 2000
- journal article
- clinical trial
- Published by Springer Nature in British Journal of Cancer
- Vol. 83 (9), 1124-1127
- https://doi.org/10.1054/bjoc.2000.1425
Abstract
One hundred and seventy-five children with Stage 3 or 4 neuroblastoma who had obtained a good response to conventional therapy were randomly allocated to 13-Cis retinoic acid at a dose of 0.75 mg/kg/day or placebo for up to 4 years. Toxicity was mild but no advantage in event-free survival was shown for the children receiving retinoic acid.Keywords
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