Liver coma was produced in 6 dogs by creating an Eck fistula and ligating the common hepatic artery in a 2-stage procedure. Intensive treatment with antibiotics and postoperative intraven. feeding with a saline-glucose soln. were essential. The dogs displayed symptoms and signs similar to those of human hepatic coma: restlessness, loss of appetite, vomiting, fever, jaundice, bradycardia, ataxia, somnolence, stupor, twitchings, convulsions, and coma. Two of the dogs died in coma; 4 survived. Of the latter 2 showed, 2-4 wks. later, signs of spinal cord lesion (spastic paraplegia). There was widespread centrolobular hemorrhagic necrosis and only small haloes of non-necrotic periportal parenchymal tissue in the livers of all animals at autopsy.