Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases
Open Access
- 1 April 2000
- journal article
- research article
- Published by Elsevier in Current Biology
- Vol. 10 (7), 401-404
- https://doi.org/10.1016/s0960-9822(00)00417-6
Abstract
No abstract availableKeywords
This publication has 17 references indexed in Scilit:
- PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathwayProceedings of the National Academy of Sciences, 1999
- New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathwayProceedings of the National Academy of Sciences, 1999
- Tumor Suppressor PTEN Inhibits Integrin- and Growth Factor–mediated Mitogen-activated Protein (MAP) Kinase Signaling PathwaysThe Journal of cell biology, 1998
- The lipid phosphatase activity of PTEN is critical for its tumor supressor functionProceedings of the National Academy of Sciences, 1998
- Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTENCell, 1998
- Inhibition of Cell Migration, Spreading, and Focal Adhesions by Tumor Suppressor PTENScience, 1998
- The Tumor Suppressor, PTEN/MMAC1, Dephosphorylates the Lipid Second Messenger, Phosphatidylinositol 3,4,5-TrisphosphateJournal of Biological Chemistry, 1998
- Rho GTPases and the Actin CytoskeletonScience, 1998
- Tumor Suppression at the Mouse INK4a Locus Mediated by the Alternative Reading Frame Product p19Cell, 1997
- [37] Cell motility assay and inhibition by Rho-GDP dissociation inhibitorMethods in Enzymology, 1995