Twenty‐Four Hour Variation in Flow and Composition of Leg Lymph in Normal Men

Abstract

The 24 h variation in concentration and output of total protein, lactate dehydrogenase and alkaline phosphatase was studied in the peripheral lymph from the legs of 5 healthy volunteers over a period of 5 days. The highest concentration of these proteins was found in lymph collected during the first 2 h after a night''s rest. During the day a continuous decrease in concentration occurred without any direct correlation to lymph flow. The variation in lymph protein concentration between early morning and late day was about 40%, lactate dehydrogenase and alkaline phosphatase about 90% and 45%, respectively.