Spontaneous Mammary Cancer Developing in Rats Born and Nursed by Mothers Treated with 3-Methylcholanthrene.
- 1 November 1960
- journal article
- research article
- Published by Frontiers Media SA in Experimental Biology and Medicine
- Vol. 105 (2), 249-252
- https://doi.org/10.3181/00379727-105-26071
Abstract
Four female rats among a total of 28 (7 males and 21 females) surviving offspring of mothers treated with 3-methylcholanthrene before pregnancy developed spontaneous mammary cancers at the age of 49, 85, 90 and 90 days. Spontaneous mammary cancer was also observed in 1 female rat among a total of 12 (3 males and 9 females) offspring of mothers treated with 3-methylcholanthrene during pregnancy. Spontaneous mammary carcinomas in rats have never been reported to appear at an age earlier than 300 days. The mechanism by which these tumors develop is of considerable interest. Present data indicate that 3-methylcholanthrene is able to pass the placental barrier.Keywords
This publication has 4 references indexed in Scilit:
- Level of 3-Methylcholanthrene in Mammary Glands of Rats after Intragastric Instillation of Carcinogen.Experimental Biology and Medicine, 1959
- Mammary Carcinogenesis by 3-Methylcholanthrene. I. Hormonal Aspects in Tumor Induction and GrowthJNCI Journal of the National Cancer Institute, 1959
- MAMMARY EXCRETION OF 20-METHYLCHOLANTHRENE1950
- CHEMICALLY INDUCED MUTATIONS AND THEIR BEARING ON CARCINOGENESISAnnals of the New York Academy of Sciences, 1947