Rate of Metabolism of Ethyl Alcohol in the Mouse.

Abstract

The rate of oxidation of alcohol was studied in the mouse by determination of the rate of decline of the concentration of alcohol in the blood as well as by determination of the alcohol content of the whole animal at various times after administration of the drug. When observations are begun one hour after administration of alcohol, the rate of oxidation is constant and independent of the amount present. However, the rate of oxidation may be twice as great in the 1st hour as in subsequent hours. The effect is dependent on dose and to some extent on mode of administration.