Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines as potential central nervous system agents. 2. Compounds containing a heteroatom attached to nitrogen
- 1 April 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (4), 610-612
- https://doi.org/10.1021/jm00214a039
Abstract
The synthesis and antitetrabenazine activity of a series of N-heteroatom derivatives of 3-phenylspiro[isobenzofuran-1,4''-piperidines] were reported. Optimal antitetrabenazine activity was associated with compounds containing a sterically unhindered, basic nitrogen. Certain hydroxylamines possessed the most significant activity with ED50s of 1.4, 3.5, 4.7, and 4.0 [in mice].This publication has 1 reference indexed in Scilit:
- Synthesis of spiro[isobenzofuran-1(3H),4'-piperidines] as potential central nervous system agents. 1Journal of Medicinal Chemistry, 1976