The Relation Between Ionization and Toxicity to Insects for Some Neuropharmacological Compounds1
- 31 March 1958
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Economic Entomology
- Vol. 51 (2), 169-175
- https://doi.org/10.1093/jee/51.2.169
Abstract
In order to study the role of ionization in the toxicity of neural poisons to insects, the authors examine the toxicity of 35 neuropharmacological agents to five insect species and the mouse. On the hypothesis that only the unionized fraction is effective in the insect, but all is effective in the mouse, toxicity ratios, mouse: insect, are calculated and compared with the observed ratios. The results confirm the hypothesis for nitrogenous anticholinester-ases, and show clearly that convulsants are intrinsically ineffective against insects. With other agents, the factors are more complex.This publication has 4 references indexed in Scilit:
- Toxicity of Fifteen Organophosphorus Insecticides to Several Insect Species and to Rats1Journal of Economic Entomology, 1957
- Properties and Metabolism in the Cockroach and Mouse of Malathion and Malaoxon1Journal of Economic Entomology, 1957
- STUDIES IN THE MODE OF ACTION OF INSECTICIDESAnnals of Applied Biology, 1952
- The effect of parathion and DDT on cholinesterase activity in the roach (Periplaneta americana L.)Biochimica et Biophysica Acta, 1951