Safety and Efficacy of Long-term Diazepam Therapy

Abstract
Clinical evidence of withdrawal phenomena and efficacy was studied in 23 long-term users of diazepam (15-60 mg daily). No withdrawal reactions were observed in the 10 patients who received placebo in a double-blind fashion for a 2 wk period. Changes in anxiety scores of both patients who received placebo and those who received diazepam suggest that the diazepam continued to be effective when used for 1 yr or longer.