TISSUE CULTURE STUDIES ON HUMAN SKIN
- 1 July 1954
- journal article
- research article
- Published by American Medical Association (AMA) in A.M.A. Archives of Dermatology and Syphilology
- Vol. 70 (1), 1-15
- https://doi.org/10.1001/archderm.1954.01540190003001
Abstract
IT IS WELL known that the available in vitro methods* for testing the fungicidal and fungistatic properties of chemicals and drugs tend to be somewhat inaccurate in that there is not close correlation between laboratory and clinical results. Obviously, one factor which seems to be important in this regard is the fact that to a considerable extent the clinical effect of the therapeutic agent depends on its capacity to penetrate keratin. However, it is possible that other factors (such as enzyme systems which may interfere with the in vivo effect of the fungicide) are involved. Therefore, in order to improve the laboratory methods of testing fungicides, it is important to attempt to duplicate in vivo conditions. In 1939 Moore,17 using the embryonated egg technique which was first described by Wolff and Israel18 and developed by Goodpasture19 and his associates, reported the successful inoculation of the chorioallantoicKeywords
This publication has 6 references indexed in Scilit:
- Histoplasma capsulatum in Tissue Culture.Experimental Biology and Medicine, 1951
- TISSUE CULTURE STUDIES ON HUMAN SKIN .1. A METHOD OF EVALUATING THE TOXICITY OF CERTAIN DRUGS EMPLOYED LOCALLY ON THE SKIN1951
- The Testing of Fungicides Insoluble in Water12Journal of Investigative Dermatology, 1945
- The chorio-allantoic membrane of the developing chick as a medium for the cultivation and histopathologic study of pathogenic fungi1941
- Studies with the Agar Cup-Plate MethodJournal of Bacteriology, 1939
- SOME USES OF THE CHICK EMBRYO FOR THE STUDY OF INFECTION AND IMMUNITY12American Journal of Epidemiology, 1938