Reduced Inflammatory Response to Plasmid DNA Vectors by Elimination and Inhibition of Immunostimulatory CpG Motifs
Open Access
- 1 March 2000
- journal article
- Published by Elsevier in Molecular Therapy
- Vol. 1 (3), 255-262
- https://doi.org/10.1006/mthe.2000.0036
Abstract
No abstract availableKeywords
This publication has 36 references indexed in Scilit:
- The Inhibitory Role of CpG Immunostimulatory Motifs in Cationic Lipid Vector-Mediated Transgene Expression in VivoHuman Gene Therapy, 1999
- DNA activates human immune cells through a CpG sequence‐dependent mannerImmunology, 1999
- CpG DNA and LPS induce distinct patterns of activation in human monocytesGene Therapy, 1999
- Minicircle: an improved DNA molecule for in vitro and in vivo gene transferGene Therapy, 1999
- Contribution of Plasmid DNA to Inflammation in the Lung after Administration of Cationic Lipid:pDNA ComplexesHuman Gene Therapy, 1999
- Direct Immunologic activities of CpG DNA and implications for gene therapyThe Journal of Gene Medicine, 1999
- Inflammatory responses following direct injection of plasmid DNA into skeletal muscleGene Therapy, 1998
- An innate immune defense mechanism based on the recognition of CpG motifs in microbial DNAJournal of Laboratory and Clinical Medicine, 1996
- Immunostimulatory DNA Sequences Necessary for Effective Intradermal Gene ImmunizationScience, 1996
- CpG motifs in bacterial DNA trigger direct B-cell activationNature, 1995