Mechanical Properties of the Lung in Cynomolgus Monkeys

Abstract

Pulmonary parameters including tidal volume, respiratory rate, minute volume, pulmonary flow resistance, dynamic compliance of the lung, and the work of breathing were measured in unanesthetized cynomolgus monkeys. A small group of animals was tested frequently during a period of 78 weeks and regression analysis of the data, including calculations of confidence limits, provided an estimate of the variation and trends in the above parameters. A digital computer technique, which was used for real-time data analysis of the recorded analog signals, was developed to elucidate the effects of long-term exposure to low levels of pulmonary irritants and urban atmospheric pollutants, such as sulfur dioxide and nitrogen dioxide.