Aspirin-like drugs interfere with arachidonate metabolism by inhibition of the 12-hydroperoxy-5,8,10,14-eicosatetraenoic acid peroxidase activity of the lipoxygenase pathway.
- 1 August 1979
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 76 (8), 3774-3778
- https://doi.org/10.1073/pnas.76.8.3774
Abstract
Aspirin, indomethacin and sodium salicylate are antiinflammatory, analgesic and antipyretic. Whereas aspirin and indomethacin inhibit human platelet prostaglandin synthetase (cyclo-oxygenase; 8,11,14-eicosatrienoate, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.1), salicylate does not. All 3 drugs affect the metabolism of arachidonate via the lipoxygenase pathway by inhibiting the conversion of 12-hydroperoxy- to 12-hydroxy-5,8,10,14-eicosatetraenoic acid.This publication has 26 references indexed in Scilit:
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