Differences between normal and milk allergic subjects in their immune responses after milk ingestion.
Open Access
- 1 March 1983
- journal article
- research article
- Published by BMJ in Archives of Disease in Childhood
- Vol. 58 (3), 201-206
- https://doi.org/10.1136/adc.58.3.201
Abstract
In order to understand why non-atopic people do not have adverse symptoms to food antigens which enter the circulation after eating, 8 non-atopic and 10 atopic eczema- and milk-allergic subjects were challenged with milk, and the types of circulating immune complexes formed were analysed. Although the amount of beta-lactoglobulin incorporated into complexes did not differ statistically between the groups, the type of immune complex did. Of the non-atopic individuals, 5 formed IgA and 2 IgG complexes. Of the milk-allergic group, all showed a rise in at least one type; 5 formed IgA, 7 IgG, 6 IgE, and 6 formed C1q-binding complexes. Our data suggest that serum IgA is concerned in safe food antigen handling in non-atopic people, and that the differences in the type of immune complexes formed in response to antigen challenge may underlie the systemic symptoms of food allergy.This publication has 20 references indexed in Scilit:
- Role of serum IgA. Hepatobiliary transport of circulating antigen.The Journal of Experimental Medicine, 1981
- Circulating IgA-immune complexes in Henoch-Schönlein purpuraAmerican Journal Of Medicine, 1980
- Systemic tolerance and secretory immunity after oral immunization.The Journal of Experimental Medicine, 1980
- Solid phase radioimmunoassay for detection of circulating food protein antigens in human serumJournal of Immunological Methods, 1980
- IgA IMMUNE COMPLEXES IN HENOCH-SCHÖNLEIN PURPURAThe Lancet, 1979
- Absorption of antigens after oral immunisation and the simultaneous induction of specific systemic tolerance.Gut, 1979
- Antigen handling by the gut.Archives of Disease in Childhood, 1978
- Rapid active transport of immunoglobulin A from blood to bile.The Journal of Experimental Medicine, 1978
- A DOUBLE-BLIND CONTROLLED CROSSOVER TRIAL OF AN ANTIGEN-AVOIDANCE DIET IN ATOPIC ECZEMAThe Lancet, 1978
- Detection of circulating immune complexes in human sera by simplified assays with polyethylene glycolJournal of Immunological Methods, 1977