The Effect of Antilipolytic Agents on Cyclic AMP, Free Fatty Acid and Total Catecholamine Concentrations in Plasma

Abstract
Plasma concentrations of cyclic[c]AMP and free fatty acids were measured in 15 patients with acute myocardial infarction and in 6 dogs given infusions of isoprenaline. Plasma total catecholamines were also estimated in the patients. Inhibition of adipose tissue lipolysis with a nicotinic acid analog [5-fluoro-3-hydroxymethylpyridine hydrochloride] did not decrease plasma cAMP concentrations, either in the patients or when elevated in the dogs, suggesting that this tissue is not a major source of the nucleotide in plasma.