The incorporation of orally administered radiolabeled dihomo γ-linolenic acid (20∶3ω6) into rat tissue lipids and its conversion to arachidonic acid
- 1 November 1978
- Vol. 13 (11), 801-803
- https://doi.org/10.1007/bf02533479
Abstract
Radioactivity from orally administered radiolabeled dihomo-γ-linolenic acid (20∶3ω6) was recovered from the liver, plasma and brain lipid fractions. After administration the fatty acid was metabolized to arachidonic acid, the 22 carbon chain length fatty acid, and was also β-oxidized. However, 22 hr after administration of [1-14C]20∶3 between one-third and one-half of the recovered radioactivity was still associated with dihomo-γ-linolenic acid in the liver and plasma lipid fractions. Orally administered dihomo-γ-linolenic acid is incorporated into lipid fractions and is, therefore, available in the metabolic pool for PGE1 synthesis.This publication has 13 references indexed in Scilit:
- The effect of dihomo-γ-linolenic acid (20: 3,n-6) on the composition of phospholipid fatty acids in the liver of rats deficient in essential fatty acidsBritish Journal of Nutrition, 1978
- Antithrombotic potential of dihomo-gamma-linolenic acid in man.BMJ, 1977
- The differential incorporation of labelled linoleic, γ‐linolenic, dihomo‐γ‐linolenic and arachidonic acids into the developing rat brainJournal of Neurochemistry, 1976
- The incorporation of orally fed radioactive γ‐linolenic acid and linoleic acid into the liver and brain lipids of suckling ratsLipids, 1975
- Enrichment of rat tissue lipids with fatty acids that are prostaglandin precursorsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1975
- Incorporation of radioactive polyunsaturated fatty acids into liver and brain of developing ratLipids, 1975
- Dihomo-γ-linolenate suppresses platelet aggregation when administered in vitro or in vivoProstaglandins, 1974
- The preferred metabolic pathway from linoleic acid to arachidonic acid in vitroBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1968
- Synthesis and metabolism of polyunsaturated acids.1961
- On the Origin of Unsaturated Fatty Acids in ClostridiaJournal of Biological Chemistry, 1961